diff --git a/CHANGELOG.md b/CHANGELOG.md
index e5783ad2f..bd5fb2282 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -41,6 +41,7 @@ This project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.htm
 - Add `go.opentelemetry.io/otel/semconv/v1.41.0` package.
   The package contains semantic conventions from the `v1.41.0` version of the OpenTelemetry Semantic Conventions.
   See the [migration documentation](./semconv/v1.41.0/MIGRATION.md) for information on how to upgrade from `go.opentelemetry.io/otel/semconv/v1.40.0`. (#8324)
+- Generate explicit histogram bucket boundaries from weaver configuration for HTTP and RPC duration instruments in `go.opentelemetry.io/otel/semconv/v1.41.0`. (#8002)
 
 ### Changed
 
diff --git a/semconv/templates/registry/go/metric.go.j2 b/semconv/templates/registry/go/metric.go.j2
index 679ddfcaa..4bfced571 100644
--- a/semconv/templates/registry/go/metric.go.j2
+++ b/semconv/templates/registry/go/metric.go.j2
@@ -53,6 +53,7 @@ var (
 {%- for metric in ctx.metrics %}
 {%- set metric_name = h.to_go_name(metric.metric_name, ctx.root_namespace) %}
 {%- set metric_inst = metric.metric_name | map_text("instrument", i.instrument_default(metric)) %}
+{%- set metric_bucket_boundaries = metric.metric_name | map_text("custom_bucket_boundaries", "") %}
 
 {{ h.metric_typedoc(metric, ctx.root_namespace) | comment | trim }}
 type {{ metric_name }} struct {
@@ -62,6 +63,9 @@ type {{ metric_name }} struct {
 var new{{ metric_name }}Opts = []metric.{{ metric_inst }}Option{
 	metric.WithDescription("{{ i.desc(metric) }}"),
 	metric.WithUnit("{{metric.unit}}"),
+{%- if metric.instrument == "histogram" and metric_bucket_boundaries != "" %}
+	metric.WithExplicitBucketBoundaries({{ metric_bucket_boundaries }}...),
+{%- endif %}
 }
 
 {{ ["New" ~ metric_name ~ " returns a new " ~ metric_name ~ " instrument."] | comment }}
diff --git a/semconv/templates/registry/go/weaver.yaml b/semconv/templates/registry/go/weaver.yaml
index 814793616..66368f5cf 100644
--- a/semconv/templates/registry/go/weaver.yaml
+++ b/semconv/templates/registry/go/weaver.yaml
@@ -86,6 +86,11 @@ text_maps:
     system.memory.usage: Int64ObservableUpDownCounter
     system.memory.utilization: Float64ObservableGauge
     system.network.io: Int64ObservableCounter
+  custom_bucket_boundaries:
+    http.client.request.duration: "[]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}"
+    http.server.request.duration: "[]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}"
+    rpc.client.call.duration: "[]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}"
+    rpc.server.call.duration: "[]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}"
 acronyms:
   - ACL
   - AI
diff --git a/semconv/v1.41.0/httpconv/metric.go b/semconv/v1.41.0/httpconv/metric.go
index 550abba38..0fa5cc074 100644
--- a/semconv/v1.41.0/httpconv/metric.go
+++ b/semconv/v1.41.0/httpconv/metric.go
@@ -739,6 +739,7 @@ type ClientRequestDuration struct {
 var newClientRequestDurationOpts = []metric.Float64HistogramOption{
 	metric.WithDescription("Duration of HTTP client requests."),
 	metric.WithUnit("s"),
+	metric.WithExplicitBucketBoundaries([]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}...),
 }
 
 // NewClientRequestDuration returns a new ClientRequestDuration instrument.
@@ -1450,6 +1451,7 @@ type ServerRequestDuration struct {
 var newServerRequestDurationOpts = []metric.Float64HistogramOption{
 	metric.WithDescription("Duration of HTTP server requests."),
 	metric.WithUnit("s"),
+	metric.WithExplicitBucketBoundaries([]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}...),
 }
 
 // NewServerRequestDuration returns a new ServerRequestDuration instrument.
diff --git a/semconv/v1.41.0/rpcconv/metric.go b/semconv/v1.41.0/rpcconv/metric.go
index 1bb450554..5799539ef 100644
--- a/semconv/v1.41.0/rpcconv/metric.go
+++ b/semconv/v1.41.0/rpcconv/metric.go
@@ -65,6 +65,7 @@ type ClientCallDuration struct {
 var newClientCallDurationOpts = []metric.Float64HistogramOption{
 	metric.WithDescription("Measures the duration of an outgoing Remote Procedure Call (RPC)."),
 	metric.WithUnit("s"),
+	metric.WithExplicitBucketBoundaries([]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}...),
 }
 
 // NewClientCallDuration returns a new ClientCallDuration instrument.
@@ -223,6 +224,7 @@ type ServerCallDuration struct {
 var newServerCallDurationOpts = []metric.Float64HistogramOption{
 	metric.WithDescription("Measures the duration of an incoming Remote Procedure Call (RPC)."),
 	metric.WithUnit("s"),
+	metric.WithExplicitBucketBoundaries([]float64{0.005, 0.01, 0.025, 0.05, 0.075, 0.1, 0.25, 0.5, 0.75, 1, 2.5, 5, 7.5, 10}...),
 }
 
 // NewServerCallDuration returns a new ServerCallDuration instrument.