diff --git a/configure b/configure
index 9ece040c7b..2d7b1bb429 100755
--- a/configure
+++ b/configure
@@ -450,7 +450,6 @@ Optimization options (experts only):
   --disable-mipsdsp        disable MIPS DSP ASE R1 optimizations
   --disable-mipsdspr2      disable MIPS DSP ASE R2 optimizations
   --disable-msa            disable MSA optimizations
-  --disable-msa2           disable MSA2 optimizations
   --disable-mipsfpu        disable floating point MIPS optimizations
   --disable-mmi            disable Loongson SIMD optimizations
   --disable-fast-unaligned consider unaligned accesses slow
@@ -2053,7 +2052,6 @@ ARCH_EXT_LIST_MIPS="
     mipsdsp
     mipsdspr2
     msa
-    msa2
 "
 
 ARCH_EXT_LIST_LOONGSON="
@@ -2592,7 +2590,6 @@ mipsdsp_deps="mips"
 mipsdspr2_deps="mips"
 mmi_deps_any="loongson2 loongson3"
 msa_deps="mipsfpu"
-msa2_deps="msa"
 
 cpunop_deps="i686"
 x86_64_select="i686"
@@ -5932,9 +5929,8 @@ elif enabled mips; then
     enabled mipsdsp && check_inline_asm_flags mipsdsp '"addu.qb $t0, $t1, $t2"' '-mdsp'
     enabled mipsdspr2 && check_inline_asm_flags mipsdspr2 '"absq_s.qb $t0, $t1"' '-mdspr2'
 
-    # MSA and MSA2 can be detected at runtime so we supply extra flags here
+    # MSA can be detected at runtime so we supply extra flags here
     enabled mipsfpu && enabled msa && check_inline_asm msa '"addvi.b $w0, $w1, 1"' '-mmsa' && append MSAFLAGS '-mmsa'
-    enabled msa && enabled msa2 && check_inline_asm msa2 '"nxbits.any.b $w0, $w0"' '-mmsa2' && append MSAFLAGS '-mmsa2'
 
     # loongson2 have no switch cflag so we can only probe toolchain ability
     enabled loongson2 && check_inline_asm loongson2 '"dmult.g $8, $9, $10"' && disable loongson3
@@ -7363,7 +7359,6 @@ if enabled mips; then
     echo "MIPS DSP R1 enabled       ${mipsdsp-no}"
     echo "MIPS DSP R2 enabled       ${mipsdspr2-no}"
     echo "MIPS MSA enabled          ${msa-no}"
-    echo "MIPS MSA2 enabled         ${msa2-no}"
     echo "LOONGSON MMI enabled      ${mmi-no}"
 fi
 if enabled ppc; then
diff --git a/libavutil/mips/generic_macros_msa.h b/libavutil/mips/generic_macros_msa.h
index bb25e9fd74..1486f7296e 100644
--- a/libavutil/mips/generic_macros_msa.h
+++ b/libavutil/mips/generic_macros_msa.h
@@ -25,10 +25,6 @@
 #include <msa.h>
 #include <config.h>
 
-#if HAVE_MSA2
-#include <msa2.h>
-#endif
-
 #define ALIGNMENT           16
 #define ALLOC_ALIGNED(align) __attribute__ ((aligned((align) << 1)))
 
@@ -1119,15 +1115,6 @@
                  unsigned absolute diff values, even-odd pairs are added
                  together to generate 8 halfword results.
 */
-#if HAVE_MSA2
-#define SAD_UB2_UH(in0, in1, ref0, ref1)                                 \
-( {                                                                      \
-    v8u16 sad_m = { 0 };                                                 \
-    sad_m += __builtin_msa2_sad_adj2_u_w2x_b((v16u8) in0, (v16u8) ref0); \
-    sad_m += __builtin_msa2_sad_adj2_u_w2x_b((v16u8) in1, (v16u8) ref1); \
-    sad_m;                                                               \
-} )
-#else
 #define SAD_UB2_UH(in0, in1, ref0, ref1)                        \
 ( {                                                             \
     v16u8 diff0_m, diff1_m;                                     \
@@ -1141,7 +1128,6 @@
                                                                 \
     sad_m;                                                      \
 } )
-#endif // #if HAVE_MSA2
 
 /* Description : Insert specified word elements from input vectors to 1
                  destination vector
@@ -2183,12 +2169,6 @@
                  extracted and interleaved with same vector 'in0' to generate
                  4 word elements keeping sign intact
 */
-#if HAVE_MSA2
-#define UNPCK_R_SH_SW(in, out)                           \
-{                                                        \
-    out = (v4i32) __builtin_msa2_w2x_lo_s_h((v8i16) in); \
-}
-#else
 #define UNPCK_R_SH_SW(in, out)                       \
 {                                                    \
     v8i16 sign_m;                                    \
@@ -2196,7 +2176,6 @@
     sign_m = __msa_clti_s_h((v8i16) in, 0);          \
     out = (v4i32) __msa_ilvr_h(sign_m, (v8i16) in);  \
 }
-#endif // #if HAVE_MSA2
 
 /* Description : Sign extend byte elements from input vector and return
                  halfword results in pair of vectors
@@ -2209,13 +2188,6 @@
                  Then interleaved left with same vector 'in0' to
                  generate 8 signed halfword elements in 'out1'
 */
-#if HAVE_MSA2
-#define UNPCK_SB_SH(in, out0, out1)                       \
-{                                                         \
-    out0 = (v4i32) __builtin_msa2_w2x_lo_s_b((v16i8) in); \
-    out1 = (v4i32) __builtin_msa2_w2x_hi_s_b((v16i8) in); \
-}
-#else
 #define UNPCK_SB_SH(in, out0, out1)                  \
 {                                                    \
     v16i8 tmp_m;                                     \
@@ -2223,7 +2195,6 @@
     tmp_m = __msa_clti_s_b((v16i8) in, 0);           \
     ILVRL_B2_SH(tmp_m, in, out0, out1);              \
 }
-#endif // #if HAVE_MSA2
 
 /* Description : Zero extend unsigned byte elements to halfword elements
    Arguments   : Inputs  - in           (1 input unsigned byte vector)
@@ -2250,13 +2221,6 @@
                  Then interleaved left with same vector 'in0' to
                  generate 4 signed word elements in 'out1'
 */
-#if HAVE_MSA2
-#define UNPCK_SH_SW(in, out0, out1)                       \
-{                                                         \
-    out0 = (v4i32) __builtin_msa2_w2x_lo_s_h((v8i16) in); \
-    out1 = (v4i32) __builtin_msa2_w2x_hi_s_h((v8i16) in); \
-}
-#else
 #define UNPCK_SH_SW(in, out0, out1)                  \
 {                                                    \
     v8i16 tmp_m;                                     \
@@ -2264,7 +2228,6 @@
     tmp_m = __msa_clti_s_h((v8i16) in, 0);           \
     ILVRL_H2_SW(tmp_m, in, out0, out1);              \
 }
-#endif // #if HAVE_MSA2
 
 /* Description : Swap two variables
    Arguments   : Inputs  - in0, in1